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Illuminating the locus coeruleus: control of posture and arousal

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Optogenetic stimulation of the locus coeruleus noradrenergic neurons can increase wakefulness, and high-frequency stimulation decreases noradrenaline levels and produces loss of muscle tone similar to that seen in cataplexy.

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Figure 1: The locus coeruleus and muscle tone regulation.

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Authors and Affiliations

  1. USA; the Department of Psychiatry and Biobehavioral Sciences, Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research, North Hills, California, University of California at Los Angeles, Los Angeles, California, USA; and the Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA.,

    Ronald McGregor & Jerome M Siegel

  2. the Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California, USA,

    Ronald McGregor & Jerome M Siegel

Authors
  1. Ronald McGregor
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  2. Jerome M Siegel
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Correspondence to Ronald McGregor or Jerome M Siegel.

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McGregor, R., Siegel, J. Illuminating the locus coeruleus: control of posture and arousal. Nat Neurosci 13, 1448–1449 (2010). https://doi.org/10.1038/nn1210-1448

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