Skip to main content
Log in

Doublecortin finds its place

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Confusing results from gene deletion experiments have left the importance of doublecortin (DCX) during brain development unclear. A report in this issue establishes a definitive function for DCX and highlights limitations of gene knockout approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: The 'double cortex' mutation.

Erin Boyle

Figure 2: Migration defects in the embryonic rat after Dcx RNA interference.

Erin Boyle

References

  1. Ross, E.M. & Walsh, C. Annu. Rev. Neurosci. 24, 1041–1070 (2001).

    Article  CAS  Google Scholar 

  2. Gleeson, J.G. et al. Cell 92, 63–72 (1998).

    Article  CAS  Google Scholar 

  3. Corbo, J.C. et al. J. Neurosci. 22, 7548–7557 (2002).

    Article  CAS  Google Scholar 

  4. Bai, J. et al. Nat. Neurosci. 6, 1277–1283 (2003).

    Article  CAS  Google Scholar 

  5. Behrends, A. & Aguzzi, A. Trends Neurosci. 25, 150–154 (2002).

    Article  Google Scholar 

  6. Olson, E.N., Arnold, H.-H., Rigby, P.W.J. & Wold, B.J. Cell 85, 1–4 (1996).

    Article  CAS  Google Scholar 

  7. Francis, F. et al. Neuron 23, 247–256 (1999).

    Article  CAS  Google Scholar 

  8. Gleeson, J.G., Lin, P.T., Flanagan, L.A. & Walsh, C. Neuron 23, 257–271 (1999).

    Article  CAS  Google Scholar 

  9. Dykxhoorn, D.M., Novina, C.D. & Sharpe, P.A. Nat. Rev. Mol. Cell Biol. 4, 457–467 (2003).

    Article  CAS  Google Scholar 

  10. Frantz, S. Nat. Rev. Drug Dis. 2, 763–764 (2003).

    Article  CAS  Google Scholar 

  11. Marin, O. & Rubenstein, J.L. Annu. Rev. Neurosci. 26, 441–483 (2003).

    Article  CAS  Google Scholar 

  12. Miyata, T., Kawaguchi, A., Okano, H. & Ogawa, M. Neuron 31, 727–741 (2001).

    Article  CAS  Google Scholar 

  13. Morest, D.K. & Silver, J. Glia 43, 6–18 (2003).

    Article  Google Scholar 

  14. Malatesta, P. et al. Neuron 37, 751–764 (2003).

    Article  CAS  Google Scholar 

  15. Gupta, A. et al. Nat. Neurosci. 6, 1284–1291 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Götz, M. Doublecortin finds its place. Nat Neurosci 6, 1245–1247 (2003). https://doi.org/10.1038/nn1203-1245

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1203-1245

  • Springer Nature America, Inc.

This article is cited by

Navigation