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Inhibiting glycolysis to reduce seizures: how it might work

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An inhibitor of glycolysis is shown to have antiepileptic effects in the rat kindling model, possibly through NADH-dependent regulation of gene expression. This may explain how the 'ketogenic diet' treatment works.

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Figure 1: A model for inhibition of kindling progression by 2DG.

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Authors and Affiliations

  1. Department of Neurobiology, Department of Medicine (Neurology) and Center for Translational Neuroscience, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Yang Zhong Huang & James O McNamara

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  1. Yang Zhong Huang
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  2. James O McNamara
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Huang, Y., McNamara, J. Inhibiting glycolysis to reduce seizures: how it might work. Nat Neurosci 9, 1351–1352 (2006). https://doi.org/10.1038/nn1106-1351

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