A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.
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Kim Caesar
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Ross, C., Cleveland, D. Intercellular miscommunication in polyglutamine pathogenesis. Nat Neurosci 9, 1205–1206 (2006). https://doi.org/10.1038/nn1006-1205
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DOI: https://doi.org/10.1038/nn1006-1205
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