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Dopamine: should I stay or should I go now?

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In C. elegans, dopamine signaling regulates locomotion behavior. Chase and colleagues report that this signaling occurs through extrasynaptic and antagonistically acting receptors coexpressed in motor neurons. These results provide surprising insights into the G-protein pathways mediating this antagonism, with implications for dopamine signaling across species.

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Figure 1: Dopamine regulation in a cholinergic motor neuron in C. elegans.
Figure 2: Model for Gαq and Gαo pathways in the nematode.

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Authors and Affiliations

  1. Department of Biology and the Brain Institute, University of Utah, Salt Lake City, 84112, Utah, USA

    Erik M Jorgensen

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  1. Erik M Jorgensen
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Jorgensen, E. Dopamine: should I stay or should I go now?. Nat Neurosci 7, 1019–1021 (2004). https://doi.org/10.1038/nn1004-1019

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