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Handling accumulated internal Cl− at inhibitory synapses

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A study in this issue finds that under conditions of intense activity at specific inhibitory synapses, the voltage gated Cl− channel CIC-2 is vital for allowing efflux of accumulated internal Cl−.

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Figure 1: Parvalbumin (PV)- and CCK-containing basket cell innervations of a typical hippocampal pyramidal cell (PyrmC).

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Authors and Affiliations

  1. The author is in the Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.,

    Trevor G Smart

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  1. Trevor G Smart
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Correspondence to Trevor G Smart.

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The author declares no competing financial interests.

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Smart, T. Handling accumulated internal Cl− at inhibitory synapses. Nat Neurosci 13, 1043–1044 (2010). https://doi.org/10.1038/nn0910-1043

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