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Unraveling the ribbon synapse

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A new study identifies pikachurin, a previously-unknown dystroglycan-binding protein that is critical for the apposition of photoreceptor and bipolar cell dendrites at the ribbon synapse. This work could explain some of the visual defects seen in several muscular dystrophies.

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Figure 1: Pikachurin is necessary for the apposition of photoreceptor and bipolar cell termini.

Kim Caesar

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Howard Hughes Medical Institute, 4283 Carver Biomedical Research Building, 285 Newton Road

    Jakob S Satz

  2. Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242, Iowa, USA

    Jakob S Satz

  3. Kevin P Campbell is also a member of the Departments of Neurology and Internal Medicine, 4283 Carver Biomedical Research Building, 285 Newton Road, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. kevin-campbell@uiowa.edu,

    Kevin P Campbell

Authors
  1. Jakob S Satz
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  2. Kevin P Campbell
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Satz, J., Campbell, K. Unraveling the ribbon synapse. Nat Neurosci 11, 857–859 (2008). https://doi.org/10.1038/nn0808-857

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  • DOI: https://doi.org/10.1038/nn0808-857

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