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Nicotinic receptor structure emerging slowly

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A high-resolution crystal structure of the ligand-binding domain of the human nicotinic acetylcholine receptor α subunit, with three point mutations to improve its crystallization, provides both reassurance and exciting new insights.

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Figure 1: The α subunit of the nAChR ligand binding domain has been resolved at high resolution.
Figure 2: Features of the new nAChR α subunit structure.

References

  1. Sine, S.M. & Engel, A.G. Nature 440, 448–455 (2006).

    Article  CAS  Google Scholar 

  2. Sixma, T.K. & Smit, A.B. Annu. Rev. Biophys. Biomol. Struct. 32, 311–334 (2003).

    Article  CAS  Google Scholar 

  3. Unwin, N. J. Mol. Biol. 346, 967–989 (2005).

    Article  CAS  Google Scholar 

  4. Brejc, K. et al. Nature 411, 269–276 (2001).

    Article  CAS  Google Scholar 

  5. Dellisanti et al., Nat. Neurosci. 10, 953–962 (2007).

    Article  CAS  Google Scholar 

  6. Bouzat, C. et al. Nature 430, 896–900 (2004).

    Article  CAS  Google Scholar 

  7. Celie, P.H. et al. Neuron 41, 907–914 (2004).

    Article  CAS  Google Scholar 

  8. Hansen, S.B. et al. EMBO J. 24, 3635–3646 (2005).

    Article  CAS  Google Scholar 

  9. Bourne, Y., Talley, T.T., Hansen, S.B., Taylor, P. & Marchot, P. EMBO J. 24, 1512–1522 (2005).

    Article  CAS  Google Scholar 

  10. Celie, P.H. et al. Nat. Struct. Mol. Biol. 12, 582–588 (2005).

    Article  CAS  Google Scholar 

  11. Miyazawa, A., Fujiyoshi, Y. & Unwin, N. Nature 423, 949–955 (2003).

    Article  CAS  Google Scholar 

  12. Yao, Y. et al. J. Biol. Chem. 277, 12613–12621 (2002).

    Article  CAS  Google Scholar 

  13. Tasneem, A., Iyer, L.M., Jakobsson, E. & Aravind, L. Genome Biol. 6, R4 (2005).

    Article  Google Scholar 

  14. Bocquet, N. et al. Nature 445, 116–119 (2007).

    Article  CAS  Google Scholar 

Download references

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Sixma, T. Nicotinic receptor structure emerging slowly. Nat Neurosci 10, 937–938 (2007). https://doi.org/10.1038/nn0807-937

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