Skip to main content
SpringerLink
Log in

Synapses, scaling and homeostasis in vivo

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

A recently identified plasticity mechanism—'synaptic scaling'—is now shown to operate in vivo to promote the stability of network function in the face of changing input activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic representation of the Desai et al. findings5.

Ivelisse Robles

References

  1. Hebb, D.O. The Organization of Behavior (Wiley, New York, 1949).

    Google Scholar 

  2. Buonomano, D.V. & Merzenich, M.M. Annu. Rev. Neurosci. 21, 149–186 (1998).

    Article  CAS  Google Scholar 

  3. Turrigiano, G.G. et al. Nature 391, 892–896 (1998).

    Article  CAS  Google Scholar 

  4. Davis, G.W. & Bezprozvanny, I. Annu. Rev. Physiol. 63, 847–869 (2001).

    Article  CAS  Google Scholar 

  5. Desai, N.S., Cudmore, R.H., Nelson, S.B. & Turrigiano, G.G. Nat. Neurosci. 5, 783–789 (2002).

    Article  CAS  Google Scholar 

  6. Turrigiano, G.G. & Nelson, S.B. Curr. Opin. Neurobiol. 10, 358–364 (2000).

    Article  CAS  Google Scholar 

  7. Murthy, V.N., Schikorski, T., Stevens, C.F. & Zhu, Y. Neuron 32, 673–682 (2001).

    Article  CAS  Google Scholar 

  8. Turrigiano, G.G. Trends Neurosci. 22, 221–227 (1999).

    Article  CAS  Google Scholar 

  9. Fagiolini, M., Pizzorusso, T., Berardi, N., Domenici, L. & Maffei, L. Vision Res. 34, 709–720 (1994).

    Article  CAS  Google Scholar 

  10. Wiesel, T.N. & Hubel, D.H. J. Neurophysiol. 6, 1029–1040 (1965).

    Article  Google Scholar 

  11. Sanes, J.R. & Lichtman, J.W. Annu. Rev. Neurosci. 22, 389–442 (1999).

    Article  CAS  Google Scholar 

  12. Miller, K.D. Neuron 17, 371–374 (1996).

    Article  CAS  Google Scholar 

  13. Song, S., Miller, K.D. & Abbot, L.F. Nat. Neurosci. 3, 919–926 (2000).

    Article  CAS  Google Scholar 

  14. van Rossum, M.C.W., Bi, G.Q. & Turrigiano, G.G. J. Neurosci. 20, 8812–8821 (2000).

    Article  CAS  Google Scholar 

  15. Miller, K.D., Pinto, D.J. & Simons, D.J. Curr. Opin. Neurobiol. 11, 488–497 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Biology, 9500 Gilman Drive, 3228 Pacific Hall, University of California at San Diego, La Jolla, 92093, California, USA

    Daniel E. Feldman

Authors
  1. Daniel E. Feldman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Feldman, D. Synapses, scaling and homeostasis in vivo. Nat Neurosci 5, 712–714 (2002). https://doi.org/10.1038/nn0802-712

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0802-712

  • Springer Nature America, Inc.

Search

Navigation