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Numb, neurogenesis and epithelial polarity

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Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.

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Figure 1: Numb localization is evolutionarily conserved in fly neuroblast and mammalian neuroepithelium.

Kim Caesar

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Authors and Affiliations

  1. Seonhee Kim and Chris A. Walsh are at the Division of Genetics, Children's Hospital Boston, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and the Program in Neuroscience, Harvard Medical School, New Research Building, Room 266, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. cwalsh@bidmc.harvard.edu,

    Seonhee Kim & Chris A Walsh

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  1. Seonhee Kim
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  2. Chris A Walsh
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The authors declare no competing financial interests.

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Kim, S., Walsh, C. Numb, neurogenesis and epithelial polarity. Nat Neurosci 10, 812–813 (2007). https://doi.org/10.1038/nn0707-812

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