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How inflammation promotes regeneration

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Macrophages near neuronal cell bodies can promote regeneration in an otherwise inhibitory environment. Now Yin et al. identify oncomodulin as a factor secreted from macrophages that promotes extensive regeneration of lesioned optic nerve axons when applied together with elevated cyclic AMP (cAMP) and mannose.

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Figure 1: Schematic representation of the number of axons and the distance they regenerated after the various treatments.

Jessica Iannuzzi

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  1. Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, 10021, New York, USA

    Marie T Filbin

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  1. Marie T Filbin
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Filbin, M. How inflammation promotes regeneration. Nat Neurosci 9, 715–717 (2006). https://doi.org/10.1038/nn0606-715

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