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Bottoms up: transduction channels at tip link bases

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A study now demonstrates that the transduction channel responsible for converting sound to neural signals in the mammalian cochlea is excluded from the tallest row of stereocilia and is instead more likely in the bottom row.

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Figure 1: Ca2+ entry during mechanotransduction.
Figure 2: Hypothetical mechanisms of transduction-channel activation.

References

  1. Denk, W., Holt, J.R., Shepherd, G.M. & Corey, D.P. Neuron 15, 1311–1321 (1995).

    Article  CAS  PubMed  Google Scholar 

  2. Lumpkin, E.A. & Hudspeth, A.J. Proc. Natl. Acad. Sci. USA 92, 10297–10301 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Beurg, M., Fettiplace, R., Nam, J. & Ricci, A.J. Nat. Neurosci. 12, 553–558 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kazmierczak, P. et al. Nature 449, 87–91 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Ricci, A.J., Crawford, A.C. & Fettiplace, R. Neuron 40, 983–990 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Bell, G.I. Science 200, 618–627 (1978).

    Article  CAS  PubMed  Google Scholar 

  7. Evans, E., Berk, D. & Leung, A. Biophys. J. 59, 838–848 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Spassova, M.A., Hewavitharana, T., Xu, W., Soboloff, J. & Gill, D.L. Proc. Natl. Acad. Sci. USA 103, 16586–16591 (2006).

    Google Scholar 

  9. Martinac, B., Adler, J. & Kung, C. Nature 348, 261–263 (1990).

    Article  CAS  PubMed  Google Scholar 

  10. Fettiplace, R. & Ricci, A.J. Curr. Opin. Neurobiol. 13, 446–451 (2003).

    Article  CAS  PubMed  Google Scholar 

  11. Gillespie, P.G. & Cyr, J.L. Annu. Rev. Physiol. 66, 521–545 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, Oregon, USA

    Kateri J Spinelli & Peter G Gillespie

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  1. Kateri J Spinelli
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  2. Peter G Gillespie
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Spinelli, K., Gillespie, P. Bottoms up: transduction channels at tip link bases. Nat Neurosci 12, 529–530 (2009). https://doi.org/10.1038/nn0509-529

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