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Photoreceptor axons play hide and seek

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The outer photoreceptors of Drosophila project to their targets in an extremely intricate pattern. Prakash et al. in this issue show that homophilic adhesion via N-cadherins is an essential part of the axon guidance mechanism in this system. The new results suggest that axons respond to the level of N-cadherins, and not to any combinatorial cadherin code, as had been postulated previously.

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Figure 1: The six outer photoreceptor cells (R1–6) from one ommatidium project to six different cartridges in the lamina (gray).

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Authors and Affiliations

  1. Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, 10003, New York, USA

    Javier Morante & Claude Desplan

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  1. Javier Morante
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  2. Claude Desplan
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Morante, J., Desplan, C. Photoreceptor axons play hide and seek. Nat Neurosci 8, 401–402 (2005). https://doi.org/10.1038/nn0405-401

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