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A proposed mechanism of ALS fails the test in vivo

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In contrast to prevailing hypotheses, a genetic study shows that the toxic gain of function associated with mutant superoxide dismutase in familial amyotropic lateral sclerosis is unlikely to be due to changes in its oxidative activity causing an increase in free radicals.

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Figure 1: Aggregates of mutant SOD1 (G37R) protein in the neurites of lumbar spinal cord motor neurons accumulates even in the complete absence of CCS.

References

  1. Halliwell, B. & Gutteridge, J. M. C. Biochem. J. 219, 1–14 (1984).

    Article  CAS  Google Scholar 

  2. Subramanian, J. R. et al. Nature Neurosci. 5, 301–307 (2002).

    Article  Google Scholar 

  3. Rosen, D. R. et al. Nature 362, 59–62 (1993).

    Article  CAS  Google Scholar 

  4. Deng, H.-X. et al. Science 261, 1047–1051 (1993).

    Article  CAS  Google Scholar 

  5. Wong, P. C. et al. Neuron 14, 1105–1116 (1995).

    Article  CAS  Google Scholar 

  6. Reaume, A. G. et al. Nature Genet . 13, 43–47 (1996).

    Article  CAS  Google Scholar 

  7. Wiedau-Pazos, M. et al. Science 271, 515–518 (1996).

    Article  CAS  Google Scholar 

  8. Estevez, A. G. et al. Science 286, 2498–2500 (1999).

    Article  CAS  Google Scholar 

  9. Torres, A. S., Petri, V., Rae, T. D. & O'Halloran, T. V. J. Biol. Chem. 276, 38410–38416 (2001).

    Article  CAS  Google Scholar 

  10. Wong, P. C. et al. Proc. Natl. Acad. Sci. USA 97, 2886–2891 (2000).

    Article  CAS  Google Scholar 

  11. Williamson, T. L. et al. Proc. Natl. Acad. Sci. USA 95, 9631–9636 (1998).

    Article  CAS  Google Scholar 

  12. Couillard-Depres, S. et al. Proc. Natl. Acad. Sci. USA 95, 9626–9630 (1998).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology and the Institute of Human Genetics at the University of Minnesota, 5-220A Moos Tower, Minneapolis, 55455, Minnesota, USA

    Harry T. Orr

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  1. Harry T. Orr
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Orr, H. A proposed mechanism of ALS fails the test in vivo. Nat Neurosci 5, 287–288 (2002). https://doi.org/10.1038/nn0402-287

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