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Surprising synapses deep in the brain

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Two independent groups in this issue report synaptic communication between callosal axons and the NG2-positive glial precursors in the brain. Activity-dependent vesicular glutamate release from axon collaterals triggers AMPA-type currents in the precursors. This phenomenon might be involved in regulation of oligodendrocyte differentiation or remyelination.

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Figure 1: NG2-expressing progenitor cells can be readily identified in subcortical white matter and in cerebral cortex of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase–enhanced green fluorescent protein mouse.

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Authors and Affiliations

  1. Vittorio Gallo is at the Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA. vgallo@cnmcresearch.org,

    Vittorio Gallo

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  1. Vittorio Gallo
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Gallo, V. Surprising synapses deep in the brain. Nat Neurosci 10, 267–269 (2007). https://doi.org/10.1038/nn0307-267

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