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A silver lining to stroke: does ischemia generate new cortical interneurons?

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New work identifies a latent population of neuronal progenitor cells in neocortical layer 1 of adult rats. These cells proliferate in response to forebrain ischemia, then integrate into the cortical network as interneurons.

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Figure 1: Transient ischemia stimulates proliferation and migration of interneuron precursors in the subpial region of the neocortex.

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Authors and Affiliations

  1. Gord Fishell is in the Department of Cell Biology and the Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York, USA,

    Gord Fishell

  2. James E. Goldman is in the Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York, USA.,

    James E Goldman

Authors
  1. Gord Fishell
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  2. James E Goldman
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Correspondence to Gord Fishell or James E Goldman.

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Fishell, G., Goldman, J. A silver lining to stroke: does ischemia generate new cortical interneurons?. Nat Neurosci 13, 145–146 (2010). https://doi.org/10.1038/nn0210-145

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