A new study shows that the identity of olfactory sensory neurons in flies is regulated by Notch signaling, which divides the neurons into two classes that express specific sets of olfactory receptors and project to distinct glomeruli.
References
Malnic, B., Hirono, J., Sato, T. & Buck, L.B. Cell 96, 713–723 (1999).
Vosshall, L.B., Wong, A.M. & Axel, R. Cell 102, 147–159 (2000).
Mombaerts, P. et al. Cell 87, 675–686 (1996).
Endo, K. et al. Nat. Neurosci. 10, 153–160 (2007).
Vassalli, A., Rothmann, A., Feinstein, P., Zapotocky, M. & Mombaerts, P. Neuron 35, 681–696 (2002).
Serizawa, S. et al. Science 302, 2088–2094 (2003)
Jefferis, G.S. & Hummel, T. Semin. Cell. Dev. Biol. 17, 50–65 (2006).
Lee, T. & Luo, L. Neuron 22, 451–461 (1999).
Lai, E.C. & Orgogozo, V. Dev. Biol. 269, 1–17 (2004).
Dobritsa, A.A., van der Goes van Naters, W., Warr, C.G., Steinbrecht, R.A. & Carlson, J.R. Neuron 37, 827–841 (2003).
Clyne, P.J. et al. Neuron 22, 327–338 (1999).
Sagasti, A., Hobert, O., Troemel, E.R., Ruvkun, G. & Bargmann, C.I. Genes Dev. 13, 1794–1806 (1999).
Lomvardas, S. et al. Cell 126, 403–413 (2006).
Wang, F., Nemes, A., Mendelsohn, M. & Axel, R. Cell 93, 47–60 (1998).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Fuss, S., Çelik, A. & Desplan, C. Olfactory identity kicked up a NOTCH. Nat Neurosci 10, 138–140 (2007). https://doi.org/10.1038/nn0207-138
Issue Date:
DOI: https://doi.org/10.1038/nn0207-138
- Springer Nature America, Inc.