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Channeling a 'funny' side of memory

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Voltage-gated ion channels shape the integration of synaptic input in dendrites. Forebrain-restricted deletion of the hyperpolarization-activated channel HCN1 enhances spatial learning, demonstrating a behavioral role for an active dendritic conductance.

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Figure 1: The loss of Ih enhances LTP specifically at distal inputs to CA1 pyramidal neurons.
Figure 2: The loss of Ih enhances temporal summation of excitatory synaptic input.

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Authors and Affiliations

  1. Center for Learning and Memory at the University of Texas at Austin, Austin, 78712, Texas, USA

    Daniel Johnston

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  1. Daniel Johnston
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Johnston, D. Channeling a 'funny' side of memory. Nat Neurosci 8, 134–135 (2005). https://doi.org/10.1038/nn0205-134

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