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Sonic Hedgehog gets another role

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A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance.

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Figure 1: Schematic diagram showing the Shh signaling pathway (adapted from ref. 3).

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  1. The author is at the University of Michigan, Biologic and Materials Sciences, Ann Arbor, Michigan, USA.,

    Catherine E Krull

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  1. Catherine E Krull
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Correspondence to Catherine E Krull.

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Krull, C. Sonic Hedgehog gets another role. Nat Neurosci 13, 6–7 (2010). https://doi.org/10.1038/nn0110-6

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