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Testing the glutamate hypothesis of schizophrenia

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A study in this issue presents a new mouse model that directly tests the glutamate hypothesis of schizophrenia. The study reports that a decrease in NMDA receptor signaling during a particular developmental window in interneurons can induce cellular and behavioral changes similar to those seen in schizophrenia.

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Figure 1: Glutamate hypothesis of schizophrenia pathogenesis.

Kim Caesar

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Authors and Affiliations

  1. The author is in the Department of Psychiatry, and the Department of Integrative Neuroscience, Columbia University College of Physicians and Surgeons, New York, New York, USA, New York State Psychiatric Institute, New York, New York, USA.,

    Joshua A Gordon

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  1. Joshua A Gordon
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Correspondence to Joshua A Gordon.

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Gordon, J. Testing the glutamate hypothesis of schizophrenia. Nat Neurosci 13, 2–4 (2010). https://doi.org/10.1038/nn0110-2

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  • DOI: https://doi.org/10.1038/nn0110-2

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