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MC4R neurons weigh in differently

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Food intake and energy expenditure were thought to be simultaneously controlled by the same group of neurons, but now new evidence shows that they are independently regulated by an anatomically distinct set of melanocortin neurons.

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Figure 1: Energy balance is achieved when food intake precisely matches energy expenditure.

References

  1. Huszar, D. et al. Cell 88, 131–141 (1997).

    Article  CAS  Google Scholar 

  2. Farooqi, I.S. et al. N. Engl. J. Med. 348, 1085–1095 (2003).

    Article  CAS  Google Scholar 

  3. Balthasar, N. et al. Cell 123, 493–505 (2005).

    Article  CAS  Google Scholar 

  4. Schwartz, M.W., Woods, S.C., Porte, D., Jr, Seeley, R.J. & Baskin, D.G. Nature 404, 661–671 (2000).

    Article  CAS  Google Scholar 

  5. Chen, H.Y. et al. Endocrinology 145, 2607–2612 (2004).

    Article  CAS  Google Scholar 

  6. Roseberry, A.G., Liu, H., Jackson, A.C., Cai, X. & Friedman, J.M. Neuron 41, 711–722 (2004).

    Article  CAS  Google Scholar 

  7. Cowley, M.A. et al. Nature 411, 480–484 (2001).

    Article  CAS  Google Scholar 

  8. Xu, A.W. et al. PLoS Biol. 3, e415 (2005).

    Article  Google Scholar 

  9. Xu, A.W. et al. J. Clin. Invest. 115, 951–958 (2005).

    Article  CAS  Google Scholar 

  10. Munzberg, H., Huo, L., Nillni, E.A., Hollenberg, A.N. & Bjorbaek, C. Endocrinology 144, 2121–2131 (2003).

    Article  CAS  Google Scholar 

  11. Pelleymounter, M.A. et al. Science 269, 540–543 (1995).

    Article  CAS  Google Scholar 

  12. Chen, A.S. et al. Transgenic Res. 9, 145–154 (2000).

    Article  CAS  Google Scholar 

  13. Marsh, D.J. et al. Nat. Genet. 21, 119–122 (1999).

    Article  CAS  Google Scholar 

  14. Farooqi, I.S. & O'Rahilly, S. Annu. Rev. Med. 56, 443–458 (2005).

    Article  CAS  Google Scholar 

  15. Ste Marie, L., Miura, G.I., Marsh, D.J., Yagaloff, K. & Palmiter, R.D. Proc. Natl. Acad. Sci. USA 97, 12339–12344 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Diabetes Center and the Department of Anatomy at the University of California San Francisco, HSW 1002, 513 Parnassus Avenue, San Francisco, 94143-0534, California, USA

    Allison W Xu

  2. Department of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, 94305, California, USA

    Gregory S Barsh

Authors
  1. Allison W Xu
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  2. Gregory S Barsh
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Xu, A., Barsh, G. MC4R neurons weigh in differently. Nat Neurosci 9, 15–16 (2006). https://doi.org/10.1038/nn0106-15

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