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Natural killers in the brain's nursery

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A previously unknown mechanism contributes to dysfunction of the neurogenic niche during CNS autoimmunity. Natural killer cells are retained specifically in the subventricular zone in chronic disease, killing stem cells and promoting pathology.

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Figure 1: Pathologic NK cells are sustained in the SVZ during chronic EAE and MS.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Department of Neuroscience, Sachin P. Gadani and Jonathan Kipnis are in the Center for Brain Immunology and Glia, Graduate Program in Neuroscience and Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.,

    Sachin P Gadani & Jonathan Kipnis

Authors
  1. Sachin P Gadani
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  2. Jonathan Kipnis
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Correspondence to Jonathan Kipnis.

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The authors declare no competing financial interests.

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Gadani, S., Kipnis, J. Natural killers in the brain's nursery. Nat Neurosci 19, 176–177 (2016). https://doi.org/10.1038/nn.4227

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