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From phenotypic chaos to neurobiological order

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Complex demographic and behavioral phenotypes can arise from coordinated interactions among brain systems. A single axis of co-variation spanning 'negative' and 'positive' attributes links diverse participant characteristics with specific patterns of brain connectivity.

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Figure 1: A single positive-negative mode of covariation links diverse demographic and behavioral phenotypes with the collective set of functional connections in the human brain.

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Authors and Affiliations

  1. Avram J. Holmes is at the Department of Psychology, Yale University, New Haven, Connecticut, USA,

    Avram J Holmes

  2. B.T. Thomas Yeo is at the Department of Electrical & Computer Engineering, Clinical Imaging Research Centre, Singapore Institute for Neurotechnology and Memory Networks Programme, National University of Singapore, Singapore.,

    B T Thomas Yeo

Authors
  1. Avram J Holmes
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  2. B T Thomas Yeo
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Correspondence to Avram J Holmes or B T Thomas Yeo.

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The authors declare no competing financial interests.

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Holmes, A., Yeo, B. From phenotypic chaos to neurobiological order. Nat Neurosci 18, 1532–1534 (2015). https://doi.org/10.1038/nn.4145

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