Skip to main content
SpringerLink
Log in

GABA receptors in a state of fear

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Our internal states can color our memories just as powerfully as the external environment. A study finds that hippocampal GABAA receptors and associated microRNAs are important for generating state-dependent contextual fear memories.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Activating hippocampal GABAA receptors generates a state-dependent contextual fear memory.

Kim Caesar/Nature Publishing Group

References

  1. Godden, D.R. & Baddeley, A.D. Br. J. Psychol. 66, 325–331 (1975).

    Article  Google Scholar 

  2. Girden, E. & Culler, E. J. Comp. Psychol. 23, 261–274 (1937).

    Article  Google Scholar 

  3. Milad, M.R. & Quirk, G.J. Annu. Rev. Psychol. 63, 129–151 (2012).

    Article  Google Scholar 

  4. Lüthi, A. & Luscher, C. Nat. Neurosci. 17, 1635–1643 (2014).

    Article  Google Scholar 

  5. Maren, S. & Holmes, A. Neuropsychopharmacology advance online publication, doi:10.1038/npp.2015.180 (29 July 2015).

    Article  Google Scholar 

  6. Jovasevic, V. et al. Nat. Neurosci. 18, 1265–1271 (2015).

    Article  CAS  Google Scholar 

  7. Sun, M.K., Nelson, T.J. & Alkon, D.L. Trends Pharmacol. Sci. 36, 384–394 (2015).

    Article  Google Scholar 

  8. Zhao, C. et al. BMC Res. Notes 5, 91 (2012).

    Article  CAS  Google Scholar 

  9. Bartel, D.P. Cell 136, 215–233 (2009).

    Article  CAS  Google Scholar 

  10. Issler, O. & Chen, A. Nat. Rev. Neurosci. 16, 201–212 (2015).

    Article  CAS  Google Scholar 

  11. Griebel, G. & Holmes, A. Nat. Rev. Drug Discov. 12, 667–687 (2013).

    Article  CAS  Google Scholar 

  12. Ressler, K.J. & Mayberg, H.S. Nat. Neurosci. 10, 1116–1124 (2007).

    Article  CAS  Google Scholar 

  13. Bouton, M.E. Biol. Psychiatry 52, 976–986 (2002).

    Article  Google Scholar 

  14. Marks, I.M. et al. Br. J. Psychiatry 162, 776–787 (1993).

    Article  CAS  Google Scholar 

  15. Bouton, M.E., Kenney, F.A. & Rosengard, C. Behav. Neurosci. 104, 44–55 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Andrew Holmes is at the Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA, and,

    Andrew Holmes

  2. Department of Neurobiology, and the Department of Stress Neurobiology and Neurogenetics, Alon Chen is at the Ruhman Family Laboratory for Research on the Neurobiology of Stress, Weizmann Institute of Science, Rehovot, Israel, Max Planck Institute of Psychiatry, Munich, Germany.,

    Alon Chen

Authors
  1. Andrew Holmes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alon Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew Holmes.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Holmes, A., Chen, A. GABA receptors in a state of fear. Nat Neurosci 18, 1194–1196 (2015). https://doi.org/10.1038/nn.4098

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.4098

  • Springer Nature America, Inc.

Search

Navigation