The hippocampus, a structure critical for memory and navigation, contains both place and episodic cell assemblies. Synchronous input from the medial septum is crucial for inducing spatial and temporal neural sequences. These sequences are, in turn, necessary for constructing episodic cells and, in the absence of sensory input, place cells.
References
Buzsáki, G. & Moser, E.I. Nat. Neurosci. 16, 130–138 (2013).
Pastalkova, E., Itskov, V., Amarasingham, A. & Buzsaki, G. Science 321, 1322–1327 (2008).
Wang, Y., Romani, S., Lustig, B., Leonardo, A. & Pastalkova, E. Nat. Neurosci. 18, 282–288 (2015).
Stewart, M. & Fox, S.E. Trends Neurosci. 13, 163–168 (1990).
Petsche, H., Stumpf, C. & Gogolak, G. Electroencephalogr. Clin. Neurophysiol. 14, 202–211 (1962).
Green, J.D. & Arduini, A.A. J. Neurophysiol. 17, 533–557 (1954).
MacDonald, C.J., Lepage, K.Q., Eden, U.T. & Eichenbaum, H. Neuron 71, 737–749 (2011).
Hasselmo, M.E. Hippocampus 15, 936–949 (2005).
Fyhn, M., Molden, S., Witter, M.P., Moser, E.I. & Moser, M.B. Science 305, 1258–1264 (2004).
Hafting, T., Fyhn, M., Molden, S., Moser, M.B. & Moser, E.I. Nature 436, 801–806 (2005).
Brandon, M.P., Koenig, J., Leutgeb, J.K. & Leutgeb, S. Neuron 82, 789–796 (2014).
Koenig, J., Linder, A.N., Leutgeb, J.K. & Leutgeb, S. Science 332, 592–595 (2011).
Wilson, M.A. & McNaughton, B.L. Science 265, 676–679 (1994).
Pavlides, C. & Winson, J. J. Neurosci. 9, 2907–2918 (1989).
Kudrimoti, H.S., Barnes, C.A. & McNaughton, B.L. J. Neurosci. 19, 4090–4101 (1999).
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Giocomo, L. Imagine a journey through time and space. Nat Neurosci 18, 163–164 (2015). https://doi.org/10.1038/nn.3926
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DOI: https://doi.org/10.1038/nn.3926
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