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Axons hooked to Schwann cell metabolism

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Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.

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Figure 1: Regulators of Schwann cell metabolism and axonal support.

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Authors and Affiliations

  1. Iva D. Tzvetanova and Klaus-Armin Nave are in the Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.,

    Iva D Tzvetanova & Klaus-Armin Nave

Authors
  1. Iva D Tzvetanova
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  2. Klaus-Armin Nave
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Correspondence to Klaus-Armin Nave.

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The authors declare no competing financial interests.

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Tzvetanova, I., Nave, KA. Axons hooked to Schwann cell metabolism. Nat Neurosci 17, 1293–1295 (2014). https://doi.org/10.1038/nn.3825

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