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Unlocking the constraints on memory formation

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A leading therapeutic molecule for multiple sclerosis, FTY720, is shown to mimic a key component of sphingolipid signaling, resulting in specific manipulation of histone deacetylases and the extinction of memory.

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Figure 1: A nuclear role for FTY720-P.

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Authors and Affiliations

  1. Dina P. Matheos and Marcelo A. Wood are in the Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA.,

    Dina P Matheos & Marcelo A Wood

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  1. Dina P Matheos
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  2. Marcelo A Wood
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Correspondence to Dina P Matheos or Marcelo A Wood.

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The authors declare no competing financial interests.

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Matheos, D., Wood, M. Unlocking the constraints on memory formation. Nat Neurosci 17, 895–896 (2014). https://doi.org/10.1038/nn.3748

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