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Wrong place, wrong time: ectopic progenitors cause cortical heterotopias

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A report reveals that giant subcortical heterotopia is caused by mutation of a microtubule-associated protein, Eml1. Defects in Eml1 lead to disruption of the radial migratory scaffolding network in mice and humans.

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Figure 1: Schematic diagram showing aspects of normal cortical development and the point at which development is disrupted in HeCo mice.

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Authors and Affiliations

  1. Laura Cocas and Samuel J. Pleasure are in the Department of Neurology San Francisco, California, USA.,

    Laura Cocas & Samuel J Pleasure

  2. Samuel J. Pleasure is in the Program in Neuroscience, Program in Developmental and Stem Cell Biology, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA.,

    Samuel J Pleasure

Authors
  1. Laura Cocas
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  2. Samuel J Pleasure
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Correspondence to Samuel J Pleasure.

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Cocas, L., Pleasure, S. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. Nat Neurosci 17, 894–895 (2014). https://doi.org/10.1038/nn.3747

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