We now learn that mutant huntingtin binds to a complex that imports constituent proteins across the mitochondrial inner membrane, halting bioenergetics in synaptic mitochondria and predisposing to neuronal dysfunction and death.
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Jonas, E. Impaired import: how huntingtin harms. Nat Neurosci 17, 747–749 (2014). https://doi.org/10.1038/nn.3726
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DOI: https://doi.org/10.1038/nn.3726
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