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Synaptic uSIRPation: the active neuron reigns over presynaptic partners

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A study reveals that SIRPα is released from postsynaptic neurons to induce and mature their synaptic inputs, using CD47 as the presynaptic receptor. SIRPα is cleaved in an activity-dependent manner to act as retrograde signal.

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Figure 1: Retrograde signaling by SIRPα allows active neurons to govern presynaptic inputs.

Marina Corral Spence

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Authors and Affiliations

  1. Thomas Biederer is in the Department of Molecular Biophysics and Biochemistry and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University, New Haven, Connecticut, USA.,

    Thomas Biederer

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  1. Thomas Biederer
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Correspondence to Thomas Biederer.

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Biederer, T. Synaptic uSIRPation: the active neuron reigns over presynaptic partners. Nat Neurosci 16, 1361–1362 (2013). https://doi.org/10.1038/nn.3523

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