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The Top3β way to untangle RNA

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With evidence from model organisms and human population genetic analysis, two studies in this issue report discoveries that eukaryotic Top3β has RNA topoisomerase activity and, in a ribonucleoprotein complex with FMRP, is important for neurodevelopment and normal cognition.

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Figure 1: Top3β is an RNA topoisomerase that, together with FMRP, is important for neurodevelopment.

References

  1. Hansen, T.B. et al. Nature 495, 384–388 (2013).

    Article  CAS  Google Scholar 

  2. Memczak, S. et al. Nature 495, 333–338 (2013).

    Article  CAS  Google Scholar 

  3. Stoll, G. et al. Nat. Neurosci. 16, 1228–1237 (2013).

    Article  CAS  Google Scholar 

  4. Xu, D. et al. Nat. Neurosci. 16, 1238–1247 (2013).

    Article  CAS  Google Scholar 

  5. Wang, H., Di Gate, R.J. & Seeman, N.C. Proc. Natl. Acad. Sci. USA 93, 9477–9482 (1996).

    Article  CAS  Google Scholar 

  6. Xu, B. et al. Nat. Genet. 44, 1365–1369 (2012).

    Article  CAS  Google Scholar 

  7. Iossifov, I. et al. Neuron 74, 285–299 (2012).

    Article  CAS  Google Scholar 

  8. Perälä, J. et al. Schizophr. Res. 106, 337–347 (2008).

    Article  Google Scholar 

  9. Hovatta, I. et al. Am. J. Med. Genet. 74, 353–360 (1997).

    Article  CAS  Google Scholar 

  10. International Schizophrenia Consortium. Nature 455, 237–241 (2008).

  11. Cooper, G.M. et al. Nat. Genet. 43, 838–846 (2011).

    Article  CAS  Google Scholar 

  12. Pieretti, M. et al. Cell 66, 817–822 (1991).

    Article  CAS  Google Scholar 

  13. Verkerk, A.J. et al. Cell 65, 905–914 (1991).

    Article  CAS  Google Scholar 

  14. Darnell, J.C. et al. Cell 146, 247–261 (2011).

    Article  CAS  Google Scholar 

  15. Wan, L., Dockendorff, T.C., Jongens, T.A. & Dreyfuss, G. Mol. Cell. Biol. 20, 8536–8547 (2000).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Brain and Cognitive Sciences, Alexi Nott and Li-Huei Tsai are at the Picower Institute for Learning and Memory, Massachusetts Institute for Technology, Cambridge, Massachusetts, USA.,

    Alexi Nott & Li-Huei Tsai

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  1. Alexi Nott
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  2. Li-Huei Tsai
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Correspondence to Li-Huei Tsai.

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The authors declare no competing financial interests.

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Nott, A., Tsai, LH. The Top3β way to untangle RNA. Nat Neurosci 16, 1163–1164 (2013). https://doi.org/10.1038/nn.3506

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