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Behavioral control by the orbital prefrontal cortex: reversal of fortune

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A study shows that selective lesions of the orbital prefrontal cortex in macaques spare behavioral flexibility and emotional processing but impair a test of outcome expectation, suggesting that some psychiatric disorders ascribed to a disrupted orbital prefrontal cortex may instead be caused by more widespread dysfunction.

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Figure 1: Schematic of OFC lesion conditions shown on a lateral view of the brain, slightly rotated to show part of the far hemisphere, and tilted up to show the OFC on the ventral surface.

Katie Vicari

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Authors and Affiliations

  1. Department of Neuroscience and Friedman Brain Institute, Mark G. Baxter and Paula L. Croxson are in the Glickenhaus Laboratory of Neuropsychology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.,

    Mark G Baxter & Paula L Croxson

Authors
  1. Mark G Baxter
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  2. Paula L Croxson
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Correspondence to Mark G Baxter.

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The authors declare no competing financial interests.

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Baxter, M., Croxson, P. Behavioral control by the orbital prefrontal cortex: reversal of fortune. Nat Neurosci 16, 984–985 (2013). https://doi.org/10.1038/nn.3472

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