Cognitive function declines as part of the normal aging process. A study finds that the dopamine-boosting drug L-DOPA changes value representation in the brain and improves reinforcement learning in older individuals.
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13 May 2013
In the version of this article initially published, author G. Elliott Wimmer's name was misspelled. The error has been corrected in the HTML and PDF versions of the article.
References
Schultz, W. Annu. Rev. Psychol. 57, 87–115 (2006).
Bäckman, L., Nyberg, L., Lindenberger, U., Li, S.C. & Farde, L. Neurosci. Biobehav. Rev. 30, 791–807 (2006).
Chowdhury, R. et al. Nat. Neurosci. 16, 648–653 (2013).
Pessiglione, M., Seymour, B., Flandin, G., Dolan, R.J. & Frith, C.D. Nature 442, 1042–1045 (2006).
Samanez-Larkin, G.R., Kuhnen, C.M., Yoo, D.J. & Knutson, B. J. Neurosci. 30, 1426–1434 (2010).
Samanez-Larkin, G.R. et al. Nat. Neurosci. 10, 787–791 (2007).
Schott, B.H. et al. Brain 130, 2412–2424 (2007).
Wunderlich, K., Smittenaar, P. & Dolan, R.J. Neuron 75, 418–424 (2012).
Samanez-Larkin, G.R., Levens, S.M., Perry, L.M., Dougherty, R.F. & Knutson, B. J. Neurosci. 32, 5333–5337 (2012).
Shohamy, D. & Adcock, R.A. Trends Cogn. Sci. 14, 464–472 (2010).
Wimmer, G.E. & Shohamy, D. Science 338, 270–273 (2012).
Peters, J. & Buchel, C. Neuron 66, 138–148 (2010).
Chowdhury, R., Guitart-Masip, M., Bunzeck, N., Dolan, R.J. & Duzel, E. J. Neurosci. 32, 14193–14204 (2012).
Samanez-Larkin, G.R. et al. Front. Neurosci. 5, 126 (2011).
Greely, H. et al. Nature 456, 702–705 (2008).
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Shohamy, D., Wimmer, G. Dopamine and the cost of aging. Nat Neurosci 16, 519–521 (2013). https://doi.org/10.1038/nn.3385
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DOI: https://doi.org/10.1038/nn.3385
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