Skip to main content
SpringerLink
Log in

The yin and yang of cortical layer 1

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Abstract

Distinct populations of layer 1 inhibitory neurons inhibit or disinhibit layer 5 pyramidal cells. A massive patch-clamp recording effort, tapping up to eight cells simultaneously, maps their influences on the cortical network.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Inhibitory neurons and their interaction with the active properties of pyramidal cells.

References

  1. Kubota, Y. et al. Cereb. Cortex 21, 1803–1817 (2011).

    Article  Google Scholar 

  2. Felleman, D.J. & Van Essen, D.C. Cereb. Cortex 1, 1–47 (1991).

    Article  CAS  Google Scholar 

  3. Gilbert, C.D. & Sigman, M. Neuron 54, 677–696 (2007).

    Article  CAS  Google Scholar 

  4. Palmer, L., Murayama, M. & Larkum, M. Front. Neural Circuits 6, 26 (2012).

    Article  CAS  Google Scholar 

  5. Xu, N.L. et al. Nature 492, 247–251 (2012).

    Article  CAS  Google Scholar 

  6. Wozny, C. & Williams, S.R. Cereb. Cortex 21, 1818–1826 (2011).

    Article  Google Scholar 

  7. Palmer, L.M. et al. Science 335, 989–993 (2012).

    Article  CAS  Google Scholar 

  8. Jiang, X., Wang, G., Lee, A.J., Stornetta, R. L & Zhu, J.J. Nat. Neurosci. 16, 210–218 (2013).

    Article  CAS  Google Scholar 

  9. Letzkus, J.J. et al. Nature 480, 331–335 (2011).

    Article  CAS  Google Scholar 

  10. Larkum, M.E., Zhu, J.J. & Sakmann, B. Nature 398, 338–341 (1999).

    Article  CAS  Google Scholar 

  11. Larkum, M.E., Senn, W. & Lüscher, H.R. Cereb. Cortex 14, 1059–1070 (2004).

    Article  Google Scholar 

  12. Olson, I.R., Chun, M.M. & Allison, T. Brain 124, 1417–1425 (2001).

    Article  CAS  Google Scholar 

  13. Crick, F. Proc. Natl. Acad. Sci. USA 81, 4586–4590 (1984).

    Article  CAS  Google Scholar 

  14. Larkum, M.E. & Zhu, J.J. J. Neurosci. 22, 6991–7005 (2002).

    Article  CAS  Google Scholar 

  15. Cardin, J.A. J. Physiol. Paris 106, 104–111 (2012).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Matthew E. Larkum is in the Neurocure Cluster of Excellence, Humboldt University of Berlin, Berlin, Germany.,

    Matthew E Larkum

Authors
  1. Matthew E Larkum
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthew E Larkum.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Larkum, M. The yin and yang of cortical layer 1. Nat Neurosci 16, 114–115 (2013). https://doi.org/10.1038/nn.3317

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3317

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation