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New game for hunger neurons

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Hypothalamic neurons that express agouti-related protein have been thought to regulate appetite by counteracting the melanocortin signaling pathway. Evidence now indicates that these neurons can also modulate dopamine signaling.

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Figure 1: Reduced activity of AgRP neurons facilitates VTA dopamine neuron activation of the nucleus accumbens.

Marina Corral

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Authors and Affiliations

  1. Richard D. Palmiter is at the Howard Hughes Medical Institute and Department of Biochemistry University of Washington, Seattle, Washington, USA.,

    Richard D Palmiter

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  1. Richard D Palmiter
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Correspondence to Richard D Palmiter.

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Palmiter, R. New game for hunger neurons. Nat Neurosci 15, 1060–1061 (2012). https://doi.org/10.1038/nn.3167

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