A study now identifies a protein that mediates the cellular transport of the lipophilic endocannabinoid anandamide in aqueous environments.
References
Devane, W.A. et al. Science 258, 1946–1949 (1992).
Fu, J., et al. Nat. Neurosci. 15, 64–69 (2011).
Maccarrone, M., Dainese, E. & Oddi, S. Trends Biochem. Sci. 35, 601–608 (2010).
Di Marzo, V. & De Petrocellis, L. Curr. Med. Chem. 17, 1430–1449 (2010).
Di Marzo, V., De Petrocellis, L., Fezza, F., Ligresti, A. & Bisogno, T. Prostaglandins Leukot. Essent. Fatty Acids 66, 377–391 (2002).
Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M. & Watanabe, M. Physiol. Rev. 89, 309–380 (2009).
McKinney, M.K. & Cravatt, B.F. Annu. Rev. Biochem. 74, 411–432 (2005).
Piomelli, D. Nat. Rev. Neurosci. 4, 873–884 (2003).
Glaser, S.T., Kaczocha, M. & Deutsch, D.G. Life Sci. 77, 1584–1604 (2005).
McFarland, M.J. & Barker, E.L. Pharmacol. Ther. 104, 117–135 (2004).
Hillard, C.J. & Jarrahian, A. Br. J. Pharmacol. 140, 802–808 (2003).
Yates, M.L. & Barker, E.L. Vitam. Horm. 81, 25–53 (2009).
Piomelli, D., Giuffrida, A., Calignano, A. & Rodriguez de Fonseca, F. Trends Pharmacol. Sci. 21, 218–224 (2000).
Di Marzo, V. Nat. Rev. Drug Discov. 7, 438–455 (2008).
Gomes, I. et al. FASEB J. 23, 3020–3029 (2009).
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Marsicano, G., Chaouloff, F. Moving bliss: a new anandamide transporter. Nat Neurosci 15, 5–6 (2012). https://doi.org/10.1038/nn.3011
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DOI: https://doi.org/10.1038/nn.3011
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