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Relax, you won't feel the pain

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Variations in the arginine vasopressin receptor gene, AVPR1A, are shown to be associated with pain sensitivity in a stress- and sex-specific manner in both mice and men.

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Figure 1: A model of how Avpr1a, stress and sex modulate pain sensitivity.

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Authors and Affiliations

  1. Tim Wiltshire is in the Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA.,

    Tim Wiltshire

  2. William Maixner and Luda Diatchenko are at the Center for Neurosensory Disorders at the University of North Carolina, Chapel Hill, North Carolina, USA.,

    William Maixner & Luda Diatchenko

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  1. Tim Wiltshire
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  2. William Maixner
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  3. Luda Diatchenko
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Correspondence to Tim Wiltshire.

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The authors declare no competing financial interests.

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Wiltshire, T., Maixner, W. & Diatchenko, L. Relax, you won't feel the pain. Nat Neurosci 14, 1496–1497 (2011). https://doi.org/10.1038/nn.2987

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