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Receptors in (e)motion

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A study finds that recall of fear-provoking memory changes the surface levels of AMPA receptors in the dorsal hippocampus. Inhibition of AMPA receptor trafficking strengthens the memory and results in excessive fear.

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Figure 1: Experimental protocols used to test the role of AMPAR trafficking in memory reconsolidation and extinction after contextual fear conditioning.

Katie Vicari

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Authors and Affiliations

  1. Jelena Radulovic and Natalie C. Tronson are in the Department of Psychiatry and Behavioral Sciences, The Asher Center for Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.,

    Jelena Radulovic & Natalie C Tronson

Authors
  1. Jelena Radulovic
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  2. Natalie C Tronson
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Correspondence to Jelena Radulovic.

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The authors declare no competing financial interests.

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Radulovic, J., Tronson, N. Receptors in (e)motion. Nat Neurosci 14, 1222–1224 (2011). https://doi.org/10.1038/nn.2938

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