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Cajal revisited: does the VMH make us fat?

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A new study used several mouse mutants to study insulin receptor function specifically in the ventromedial nucleus of the hypothalamus (VMH), and found a role for VMH insulin signaling in promoting high-fat diet–induced obesity.

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Figure 1: The chemoarchitecture of the VMH and its contact with local neuronal and humoral inputs.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine, Chun-Xia Yi and Matthias H. Tschöp are at the Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, USA.,

    Chun-Xia Yi & Matthias H Tschöp

  2. Thomas Scherer is in the Division of Endocrinology, Department of Medicine, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, USA.,

    Thomas Scherer

Authors
  1. Chun-Xia Yi
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  2. Thomas Scherer
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  3. Matthias H Tschöp
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Correspondence to Matthias H Tschöp.

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Yi, CX., Scherer, T. & Tschöp, M. Cajal revisited: does the VMH make us fat?. Nat Neurosci 14, 806–808 (2011). https://doi.org/10.1038/nn.2867

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