Skip to main content
SpringerLink
Log in

L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

  • Brief Communication
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Abstract

The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca2+ channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC–mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Differential role of distinct VDCC subtypes in synaptic transmission and plasticity.
Figure 2: L-VDCC mediate expression of presynaptic LTP.

Similar content being viewed by others

References

  1. Malinow, R. & Malenka, R.C. Annu. Rev. Neurosci. 25, 103–126 (2002).

    Article  CAS  Google Scholar 

  2. Nicoll, R.A. & Schmitz, D. Nat. Rev. Neurosci. 6, 863–876 (2005).

    Article  CAS  Google Scholar 

  3. Catterall, W.A. Annu. Rev. Cell Dev. Biol. 16, 521–555 (2000).

    Article  CAS  Google Scholar 

  4. Catterall, W.A. & Few, A.P. Neuron 59, 882–901 (2008).

    Article  CAS  Google Scholar 

  5. Mato, S. et al. Neuropharmacology 54, 87–94 (2008).

    Article  CAS  Google Scholar 

  6. Pelkey, K.A., Topolnik, L., Lacaille, J.C. & McBain, C.J. Neuron 52, 497–510 (2006).

    Article  CAS  Google Scholar 

  7. LeDoux, J.E. Annu. Rev. Neurosci. 23, 155–184 (2000).

    Article  CAS  Google Scholar 

  8. Humeau, Y., Shaban, H., Bissière, S. & Lüthi, A. Nature 426, 841–845 (2003).

    Article  CAS  Google Scholar 

  9. Fourcaudot, E. et al. Proc. Natl. Acad. Sci. USA 105, 15130–15135 (2008).

    Article  CAS  Google Scholar 

  10. Castillo, P.E., Weisskopf, M.G. & Nicoll, R.A. Neuron 12, 261–269 (1994).

    Article  CAS  Google Scholar 

  11. Fisher, R.E., Gray, R. & Johnston, D. J. Neurophysiol. 64, 91–104 (1990).

    Article  CAS  Google Scholar 

  12. Coppola, T. et al. J. Biol. Chem. 276, 32756–32762 (2001).

    Article  CAS  Google Scholar 

  13. Kiyonaka, S. et al. Nat. Neurosci. 10, 691–701 (2007).

    Article  CAS  Google Scholar 

  14. Bauer, E.P., Schafe, G.E. & LeDoux, J.E. J. Neurosci. 22, 5239–5249 (2002).

    Article  CAS  Google Scholar 

  15. Shinnick-Gallagher, P., McKernan, M.G., Xie, J. & Zinebi, F. Ann. NY Acad. Sci. 985, 135–149 (2003).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank J. Letzkus and all members of the Lüthi laboratory for helpful discussions and comments on the manuscript. This study was supported by the Agence Nationale pour la Recherche, the European Neuroscience Institutes Network, the Eucor Learning and Teaching Mobility Program, the Swiss National Science Foundation, the Austrian Science Fund and the Novartis Research Foundation.

Author information

Author notes

  1. Elodie Fourcaudot and Frederic Gambino: These authors contributed equally to this work.

Authors and Affiliations

  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Elodie Fourcaudot, Guillaume Casassus, Yann Humeau & Andreas Lüthi

  2. Centre National de la Recherche Scientifique, Strasbourg, UPR3212, France

    Elodie Fourcaudot, Frederic Gambino, Bernard Poulain & Yann Humeau

Authors
  1. Elodie Fourcaudot
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frederic Gambino
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guillaume Casassus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bernard Poulain
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yann Humeau
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Andreas Lüthi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

E.F., F.G, G.C., B.P., Y.H. and A.L. designed the study. E.F., F.G., G.C. and Y.H. carried out the experiments. E.F., F.G., G.C., B.P., Y.H. and A.L. analyzed the data. E.F., G.C., B.P., Y.H. and A.L. wrote the manuscript.

Corresponding author

Correspondence to Andreas Lüthi.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–3 and Supplementary Methods (PDF 339 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fourcaudot, E., Gambino, F., Casassus, G. et al. L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala. Nat Neurosci 12, 1093–1095 (2009). https://doi.org/10.1038/nn.2378

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.2378

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation