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Structural biology: Loading T4SS substrates

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Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.

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Figure 1: Speculative models depicting possible spatial arrangements for the DotL–Dot/Icm channel.

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Authors and Affiliations

  1. the Department of Microbiology and Molecular Genetics, McGovern Medical School, 6431 Fannin Street, Houston, 77030, Texas, USA

    Peter J. Christie

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  1. Peter J. Christie
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Correspondence to Peter J. Christie.

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Christie, P. Structural biology: Loading T4SS substrates. Nat Microbiol 2, 17125 (2017). https://doi.org/10.1038/nmicrobiol.2017.125

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