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Bacterial genomics: Microbial GWAS coming of age

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A linear-mixed modelling genome-wide association approach for detecting genes and genetic variants underlying antibiotic resistance in bacterial pathogens heralds a new era for microbial genome-wide association studies.

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Figure 1: Genome-wide association studies (GWAS) are performed according to similar principles in humans (left) and bacteria (right) but controlling for the possible confounding effects of genomic relatedness (here shown using a phylogenetic tree) is particularly important in bacterial GWAS.

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  1. Daniel Falush is at the Institute of Life Science-1, Room 121, Swansea University, College of Medicine, Swansea, SA2 8PP, UK.,

    Daniel Falush

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  1. Daniel Falush
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Correspondence to Daniel Falush.

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Falush, D. Bacterial genomics: Microbial GWAS coming of age. Nat Microbiol 1, 16059 (2016). https://doi.org/10.1038/nmicrobiol.2016.59

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