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Viral infection: A key host receptor for AAV

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A transmembrane protein receptor that is critical for adeno-associated virus infection has been identified through an unbiased, genome-wide screen. Its role in viral entry could potentially be harnessed to develop enhanced gene therapy vectors and better animal models of human disease.

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Figure 1: The role of AAVR in AAV cellular entry.

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Authors and Affiliations

  1. Sabrina Sun and David V. Schaffer are in the Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, USA.,

    Sabrina Sun & David V. Schaffer

  2. David V. Schaffer is also in the Department of Bioengineering, the Department of Cell and Molecular Biology and the Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA.,

    David V. Schaffer

Authors
  1. Sabrina Sun
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  2. David V. Schaffer
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Correspondence to David V. Schaffer.

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Sun, S., Schaffer, D. Viral infection: A key host receptor for AAV. Nat Microbiol 1, 15027 (2016). https://doi.org/10.1038/nmicrobiol.2015.27

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