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Next-generation sequencing transforms today's biology

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A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

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Acknowledgements

I thank W. Miller and N. Wittekindt for suggestions on the manuscript. The author is funded in part by the Gordon and Betty Moore Foundation.

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  1. Stephan C. Schuster is at Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA. scs@bx.psu.edu,

    Stephan C Schuster

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Schuster, S. Next-generation sequencing transforms today's biology. Nat Methods 5, 16–18 (2008). https://doi.org/10.1038/nmeth1156

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