Skip to main content
SpringerLink
Log in

You too can play with an edge

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

Abstract

Strategies for the systematic isolation of alleles that selectively disrupt only one or a few interactions of the encoded protein will aid in the dissection of gene function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

References

  1. Dreze, M. et al. Nat. Methods 6, 843–849 (2009).

    Article  CAS  Google Scholar 

  2. Ear, P.H. & Michnick, S.W. Nat. Methods 6, 813–816 (2009).

    Article  CAS  Google Scholar 

  3. Dixon, S.J., Costanzo, M., Baryshnikova, A., Andrews, B. & Boone, C. Annu. Rev. Genet. advance online publication, doi:10.1146/annurev.genet.39.073003.114751 (27 August 2009).

  4. Varadarajan, R., Nagarajaram, H.A. & Ramakrishnan, C. Proc. Natl. Acad. Sci. USA 93, 13908–13913 (1996).

    Article  CAS  Google Scholar 

  5. Amberg, D.C., Basart, E. & Botstein, D. Nat. Struct. Biol. 2, 28–35 (1995).

    Article  CAS  Google Scholar 

  6. Wertman, K.F., Drubin, D.G. & Botstein, D. Genetics 132, 337–350 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Tong, A. et al. Science 303, 808–813 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brenda Andrews and Charles Boone are at the Banting and Best Department of Medical Research and Department of Molecular Genetics, Michael Costanzo, Anastasia Baryshnikova, Corey Nislow, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.,

    Michael Costanzo, Anastasia Baryshnikova, Corey Nislow, Brenda Andrews & Charles Boone

Authors
  1. Michael Costanzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anastasia Baryshnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Corey Nislow
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Brenda Andrews
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charles Boone
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Costanzo, M., Baryshnikova, A., Nislow, C. et al. You too can play with an edge. Nat Methods 6, 797–798 (2009). https://doi.org/10.1038/nmeth1109-797

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth1109-797

  • Springer Nature America, Inc.

Search

Navigation