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In living color: DNA methyltransferase caught in the act

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Since the 1970s, fluorescence recovery after photobleaching has advanced our understanding of cell membrane dynamics and cytoplasmic signaling pathways. This technique has now been applied in the nucleus to address questions in epigenetics and provides a useful new tool to develop pharmacotherapies for human disease.

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Figure 1: Schematic representation of the DNA methyltransferase (Dnmt) trapping assay.

Katie Ris

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Authors and Affiliations

  1. the Laboratory of Cancer Biology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, 21231, Maryland, USA

    Kornel Schuebel & Steve Baylin

Authors
  1. Kornel Schuebel
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  2. Steve Baylin
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Schuebel, K., Baylin, S. In living color: DNA methyltransferase caught in the act. Nat Methods 2, 736–738 (2005). https://doi.org/10.1038/nmeth1005-736

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  • DOI: https://doi.org/10.1038/nmeth1005-736

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