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Soaking up small RNAs

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MicroRNAs are not amenable to classical RNAi-based knockdown strategies, but genetic 'sponges' that compete microRNAs away from their natural targets create a microRNA 'knockdown'.

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Figure 1: miRNA sponges interfere with miRNA function.

Katie Ris-Vicari

References

  1. Wightman, B., Ha, I. & Ruvkun, G. Cell 75, 855–862 (1993).

    Article  CAS  Google Scholar 

  2. Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).

    CAS  Google Scholar 

  3. Griffiths-Jones, S. Nucleic Acids Res. 32, D109–D111 (2004).

    Article  CAS  Google Scholar 

  4. Ebert, M.S., Neilson, J.R. & Sharp, P.A. Nat. Methods 4, 721–726 (2007).

    Article  CAS  Google Scholar 

  5. Kim, V.N. Nat. Rev. Mol. Cell Biol. 6, 376–385 (2005).

    Article  CAS  Google Scholar 

  6. Hammond, S.M. Nat. Methods 3, 12–13 (2006).

    Article  CAS  Google Scholar 

  7. Shi, R. & Chiang, V.L. Biotechniques 39, 519–525 (2005).

    Article  CAS  Google Scholar 

  8. Chen, C. et al. Nucleic Acids Res. 33, e179 (2005).

    Article  Google Scholar 

  9. Hutvagner, G., Simard, M.J., Mello, C.C. & Zamore, P.D. PLoS Biol. 2, E98 (2004).

    Article  Google Scholar 

  10. Meister, G., Landthaler, M., Dorsett, Y. & Tuschl, T. RNA 10, 544–550 (2004).

    Article  CAS  Google Scholar 

  11. Orom, U.A., Kauppinen, S. & Lund, A.H. Gene 372, 137–141 (2006).

    Article  CAS  Google Scholar 

  12. Thai, T.H. et al. Science 316, 604–608 (2007).

    Article  CAS  Google Scholar 

  13. Zhao, Y. et al. Cell 129, 303–317 (2007).

    Article  CAS  Google Scholar 

  14. van Rooij, E. et al. Science 316, 575–579 (2007).

    Article  CAS  Google Scholar 

  15. Rodriguez, A. et al. Science 316, 608–611 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 27599, North Carolina, USA

    Scott M Hammond

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  1. Scott M Hammond
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Hammond, S. Soaking up small RNAs. Nat Methods 4, 694–695 (2007). https://doi.org/10.1038/nmeth0907-694

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