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Hunting for ion channel modulators with herpes simplex virus

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An innovative use of HSV-1 vectors lays the foundation for a novel genetic screen for modulators of ligand-gated ion channels.

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Figure 1: Schematic description of the genetic selection for a TRPV1 dominant negative subunit.

Katie Ris-Vicari

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Authors and Affiliations

  1. Marianne E. Buck and James E. Krause are in the Department of Biochemistry and Molecular Biology, Daniel N. Cortright, Neurogen Corporation, Branford, Connecticut 06405, USA. dcortright@nrgn.com,

    Daniel N Cortright, Marianne E Buck & James E Krause

Authors
  1. Daniel N Cortright
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  2. Marianne E Buck
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  3. James E Krause
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Competing interests

All of the authors work for the Neurogen Corporation, which is in the business of identifying novel drug therapies, some of which may target ion channels such as Trpv1.

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Cortright, D., Buck, M. & Krause, J. Hunting for ion channel modulators with herpes simplex virus. Nat Methods 4, 692–693 (2007). https://doi.org/10.1038/nmeth0907-692

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