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Eris: an automated estimator of protein stability

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Figure 1: Performance of Eris.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, 27599, North Carolina, USA

    Shuangye Yin, Feng Ding & Nikolay V Dokholyan

Authors
  1. Shuangye Yin
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  2. Feng Ding
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  3. Nikolay V Dokholyan
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The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

Comparison of Eris ΔΔG calculations with those from other servers. (PDF 87 kb)

Supplementary Table 1

List of the Δn1 > 0 class mutants, the relative solvent accessibilities (RSA) of the mutated residues, the experimental measured ΔΔG, and the evaluated ΔΔG values by various servers. (PDF 75 kb)

Supplementary Table 2

Eris-aided structure pre-relaxation relieves backbone strains of the α-spectrin initial structure. (PDF 36 kb)

Supplementary Methods (PDF 97 kb)

Supplementary Discussion (PDF 149 kb)

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Yin, S., Ding, F. & Dokholyan, N. Eris: an automated estimator of protein stability. Nat Methods 4, 466–467 (2007). https://doi.org/10.1038/nmeth0607-466

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