A new algorithm for identifying evolutionary constraint incorporates information on local DNA topology, and leads to the finding that this topology is conserved across species.
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References
Parker, S.C.J. et al. Local DNA topography correlates with functional noncoding regions of the human genome. Science advance online publication (12 March 2009).
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de Souza, N. Sequence is not everything. Nat Methods 6, 320–321 (2009). https://doi.org/10.1038/nmeth0509-320b
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DOI: https://doi.org/10.1038/nmeth0509-320b
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